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Inhibition of Aurora B kinase (AURKB) enhances the effectiveness of 5-fluorouracil chemotherapy against colorectal cancer cells | British Journal of Cancer

Nature
5-Fluorouracil (5-FU) remains a core component of systemic therapy for colorectal cancer (CRC). However, response rates remain low, and development of...
10 months ago

Ecological transformation is the key to improve ecosystem health for resource-exhausted cities: A case study in China based on future development scenarios

ScienceDirect.com
A multi-objective optimization model was constructed to predict land use changes under four future development scenarios (four ecological transformation modes)
7 months ago

Bay County Sheriff's Office

Facebook
March 19, 2024 Bay County Sheriff Tommy Ford announced today the arrest of a local man on 13 charges of Video Voyeurism. In mid-February 2024, the Bay...
8 months ago

A function-based mapping of sensory integration along the cortical hierarchy

Nature
Sensory information mainly travels along a hierarchy spanning unimodal to transmodal regions, forming multisensory integrative representations crucial for...
3 days ago

Remote loop evolution reveals a complex biological function for chitinase enzymes beyond the active site

Nature
Loops are small secondary structural elements that play a crucial role in the emergence of new enzyme functions. However, the evolutionary molecular...
7 months ago

Why are not all eligible chronic myeloid leukemia patients willing to attempt tyrosine kinase inhibitor discontinuation? A Czech nationwide analysis related to the TKI stopping trial HALF

Nature
Tyrosine kinase inhibitor (TKI) therapy discontinuation with the aim of achieving treatment-free remission (TFR) is becoming more frequent, as an increasing...
8 months ago

Local energetic frustration conservation in protein families and superfamilies

Nature
Energetic local frustration offers a biophysical perspective to interpret the effects of sequence variability on protein families.
11 months ago

A splicing site change between exon 5 and 6 of the nuclear-encoded chloroplast-localized HvYGL8 gene results in reduced chlorophyll content and plant height in barley

Frontiers
The chloroplast is an important cellular organelle and metabolic hub, which is not only responsible for plant photosynthesis but is also involved in the de...
11 months ago

Sick building syndrome: do outdoor pollutants and pollen affect it?

Frontiers
IntroductionSick building syndrome (SBS) refers to non-specific complaints, including upper-respiratory irritative symptoms, headaches, fatigue, and rash,...
4 months ago

Sustainable-use marine protected areas provide co-benefits to human nutrition

ScienceDirect.com
Sustainable-use MPAs contribute up to 14% of global fisheries nutrient supply. MPAs can enhance nutrition via increased fisheries, tourism, and ancillary...
1 month ago